Application of Probiotics in Gastrointestinal-Related Diseases

Probiotics, when used in appropriate amounts, can effectively treat gastrointestinal-related diseases and confer health benefits on the host. Creative Enzymes offers a wide range of probiotic-related products and services to help our clients prevent disease and improve health. Our advanced technology platform can accelerate the development of probiotic therapies. We provide basic research including the mechanism of probiotic interaction with different organs and the relationship between probiotics and symbiotic microorganisms, which can provide more targeted therapeutic factors to deepen the efficacy of probiotics and their research areas.

Fig. 1 General probiotic mechanism of action in pediatric gastrointestinal infections. (Plaza-Díaz, 2018)

The Role of Probiotics in Gastrointestinal Diseases

The mechanism by which probiotics improve gastrointestinal disorders is heterogeneous, strain-specific, and dependent on the number of available bacteria. Therefore, the administration of probiotics, especially Lactic acid bacteria, exerts beneficial effects in the following ways.

• Modulation and normalization of perturbed intestinal microbial communities.
• Competitive exclusion of pathogens such as Staphylococcus aureus and Salmonella typhimurium, among others.
• Bacteriocin and SCFA production.
• Enzymatic activities related to metabolization of a number of carcinogens and other toxic substances.
• Adhesion to mucosal cells, cell antagonism, and mucin production.
• Intestinal permeability reduction by tight junctions protein modulation (e.g., zonulin, claudin, occludin, junctional adhesion molecule).
• Modulation of the immune system by stimulating Tregs cells, IgA production by B cells, and NF-kβ signaling pathway inhibition.
• Interaction with the brain-gut axis via the generation of bacterial metabolites.

Probiotics That Prevent and Treat Gastrointestinal Diseases

Different probiotic strains have different effects. Here is a brief overview of some of the probiotic strains we offer for gastrointestinal disorders and how they can improve and treat gastrointestinal disorders.

• Acute Infectious Diarrhea

Acute infectious diarrhea is the leading cause of morbidity in children. Lactobacillus rhamnosus GG and Lactobacillus Reuteri and Bifidobacterium bifidum can be used to prevent acute infections. These probiotics can significantly reduce the severity of diarrhea and enhance host immunity.

• Antibiotic-Associated Diarrhea (AAD)

Probiotics can significantly reduce the incidence of pediatric AAD and pediatric C. difficile infection.Streptococcus boulardii and Lactobacillus rhamnosus GG are two of the best researched strains to prevent AAD by restoring intestinal flora.

• Traveler's Diarrhea (TD)

Traveler's diarrhea is a common disease with significant socioeconomic impact, and the Lactobacillus acidophilus and Lactobacillus rhamnosus GG have shown significant efficacy in preventing TD.

• Irritable Bowel Syndrome (IBS)

IBS is a common functional gastrointestinal disorder and the use of probiotics can accelerate gastrointestinal motility, visceral hypersensitivity, intestinal microbiota, intestinal epithelium and immune function. Lactobacillus and Bifidobacterium have been shown to be effective in improving the symptoms of IBS.

• Helicobacter Pylori

Intaking of Bifidobacterium bifidum and Lactobacillus acidophilus has an impact on Helicobacter pylori infection in humans, boosting the immune effect and alleviating diarrheal symptoms.

• Constipation

Bifidobacterium lactis significantly alters the regularity of bowel movements and increases specific short-chain fatty acids that both lubricate the colon and provide energy to the smooth muscle of the intestinal wall.

• Necrotizing Enterocolitis (NEC)

Neonatal necrotizing enterocolitis (NEC) is an inflammatory necrotizing disease involving the intestine that is unique to the neonatal period. Lactobacillus rhamnosus, Lactobacillus reuteri, Bifidobacterium infantis, Bifidobacterium and Clostridium butyricum are effective in reducing morbidity and mortality in NEC.

Our Capabilities

• Screening and characterization of promising probiotics.
• Development of probiotic formulations for specific indications.
• Development of recombinant bacterial strains and testing their role in different disease models.
• Studying the mechanism of action of probiotics and how they interact with the organism/microenvironment.

Creative Enzymes is a professional and experienced probiotic supplier and service provider. Our expertise in probiotic formulation and manufacturing means we know how to guide you through the entire process, from strain screening to high-quality gastrointestinal products. To get more information, please contact us and we will be happy to serve your research demands.

Reference

1. Plaza-Díaz, J.; et al. Immune-mediated mechanisms of action of probiotics and synbiotics in treating pediatric intestinal diseases. Nutrients. 2018, 10(1): 42.