Assessing the Effect of Probiotics on Seriously Ill or Immunocompromised Hosts
Creative Enzymes combines our science with multiple animal models to continuously explore the potential mechanisms and health effects of probiotics on hosts. Our cross-functional team is on hand to provide the support and expertise you need for your probiotic products.
Overview
Reports of adverse reactions of probiotics in different consumer groups have led to ongoing concerns about their safety. In particular, safety concerns in some high-risk or immunocompromised hosts. These groups include infants, the elderly, hospitalized patients, and patients with immune deficiencies due to genetic or acquired diseases. Some probiotics are closely related to pathogens can transfer antibiotic resistance genes. And certain gut bacteria may cause inflammation and autoimmune disease in immunodeficient hosts. The use of animal models is a good tool to research the effect of probiotics on critically ill or immunocompromised hosts from in vivo. Among them, animal models of colitis, immunodeficiency and endocarditis are the more used animal models in probiotic safety studies.
Fig. 1 Epithelial barrier disturbance by either proinflammatory mediators or antibiotics. (Schuijt, 2013)
Animal Models for Assessing the Effects of Probiotics on Critically Ill or Immunocompromised Hosts
Despite the well documented safe use of probiotics, in rare cases they can be isolated from infections in severely ill individuals. For this reason, most of the models used to evaluate the safety of probiotics correspond to different disease models. Creative Enzymes offers a variety of animal models for studying the potential effects of probiotics on immunodeficient hosts, including spontaneous and late artificially induced models.
The following table describes the animal models we provide.
| Animal Models | Description |
|---|---|
| Colitis Model | Colitis models are used to simulate the physiological and pathological symptoms associated with colitis and are commonly used to evaluate the risk of bacterial translocation associated with intestinal barrier disorders. |
| Endocarditis Model | It is used to simulate the physiological and pathological symptoms associated with endocarditis and is often used more frequently in probiotic safety studies to assess the potential toxicity risk of probiotics. |
| Acute Pancreatitis Rat Model | For simulating the physiological and pathological symptoms associated with acute pancreatitis. The use of a rat model of acute pancreatitis allows for studies on the efficacy and safety of mixed probiotics. |
| Immunodeficiency Model | It is used to simulate immunodeficient patients. The animal models used include juvenile, adult, congenital immunodeficiency and several types of acquired induction. |
| Other Models | Induced severe liver injury model, Worm susceptibility model, Interleukin deficiency model and intestinal resection model, etc. |
Creative Enzymes is a professional and experienced probiotic supplier and service provider. We leverage the breadth of our expertise to accelerate our customers' product development and provide consumers with truly valuable and safe products. To get more information, please contact us and we will be happy to serve your research demands.
Reference
- Schuijt, T. J.; et al. The intestinal microbiota and host immune interactions in the critically ill. Trends in microbiology. 2013, 21(5): 221-229.
