Application of Probiotics in Cancer Prevention and Therapy
Cancer is considered one of the causes of human death and the risk of developing cancer depends on genetic factors as well as the immune status of the body. Some probiotic strains that modulate the gut microbiota and immune response can be used for cancer prevention or as adjuvant therapy during anticancer chemotherapy. Creative Enzymes can provide a wide range of scientifically proven probiotics for cancer prevention and treatment. In addition, we offer a variety of of high-quality services to expand the applications of probiotics in cancer therapy, including personalization of probiotics, efficacy and safety assessment, and anti-cancer mechanism research.
Mechanism of Probiotics Action in Cancer Prevention and Therapy
The mechanisms of action of probiotics in cancer prevention and treatment include the following.
- Altering the composition and metabolic activity of the intestinal microbiota.
- Production of compounds with anticancer activity, such as short-chain fatty acids and conjugated linoleic acid.
- Inhibition of cancer cell proliferation and induction of apoptosis.
- Influencing other mutagenic and carcinogenic factors.
- Binding and degradation of carcinogenic compounds present in the intestinal lumen.
- Immunomodulation and improvement of the intestinal barrier.
Fig. 1 Potential mechanisms of probiotics action in the prevention of colorectal cancer development. (Śliżewska, 2020)
Probiotics to Prevent and Treat Cancer
Creative enzymes can provide a wide range of probiotic strains. Some of these probiotic strains can be used as adjuvants in cancer prevention or treatment. These specific microbial strains can be used alone or in combination with cancer therapeutics. The therapeutic goal is achieved by activating immune surveillance against the cancer. The table below describes some of the applications of our strains in cancer prevention and treatment.
| Probiotics | Cancer Type | Forms of Probiotics or Their Secretion | Regulation Points |
|---|---|---|---|
| E. faecium | Colorectal Cancer (CRC) | Live | Cell apoptosis. |
| L. casei | CRC | Live | Apoptosis-inducing ligand TRAIL upregulation and survivin downregulation. |
| L. plantarum | CRC | Live | Carcinogen binding and degrading; antitumorigenic production or increasing the host's immune response. |
| L. acidophilus | Breast cancer | Live | Activating innate anti-cancer cells. |
| L. lactis | Lung | Live | Decreases nitric oxide production and pro-inflammatory cytokines. |
| S. thermophilus | CRC | Live | Carcinogens binding and degrading, immune response increment, antimutagenic. |
| Recombinant L. casei | CRC | Live | TH17 immune response. |
| L. casei and L. rhamnosus GG | CRC | Protein, nucleic acid, or polysaccharide | Decrease metalloproteinase-9 activity and increase the levels of zona occludens-1. |
Our Capabilities
- Providing probiotic strains or prebiotics for cancer prevention and treatment and for mitigating anti-tumor related side effects.
- Providing customized probiotic or prebiotic formulations for the effective prevention and treatment of different cancers and the mitigation of anti-tumor related side effects.
- Evaluating the efficacy and safety of probiotics associated with the prevention and treatment of cancer.
- Studying the anticancer properties of specific probiotic strains and their mechanisms of action.
Creative Enzymes is a professional and experienced probiotic supplier and service provider. Our screened and validated high-quality strains are ideal for use in cancer prevention and treatment. In addition, our expertise allows us to develop health products with multiple delivery formats for our clients. To get more information, please contact us and we will be happy to serve your research demands.
References
- Śliżewska, K.; et al. The role of probiotics in cancer prevention. Cancers. 2020, 13(1): 20.
- Bedada, T. L.; et al. Probiotics for cancer alternative prevention and treatment. Biomedicine & pharmacotherapy. 2020, 129: 110409.
