Applications of Probiotics in Disease Control

Probiotics can not only improve our health and control pathogenic infections, but can also help in the treatment and management of diseases. As a leading guide to the probiotic industry, Creative Enzymes offers safe probiotic strains that can be used in the treatment of many diseases. We can also provide custom probiotic formulations for customer-specific health demands. In addition, we can help our clients research the role of probiotics and their related products in disease management.

Overview

The results of many clinical studies suggest that probiotics may help prevent and treat a variety of health conditions and diseases. Potential applications of probiotics include the prevention and treatment of various health conditions and diseases such as gastrointestinal infections, inflammatory bowel disease, lactose intolerance, allergies, genitourinary infections, cystic fibrosis, various cancers, reduction of antibiotic side effects, oral health, and many other impacts that are being studied.

Fig. 1 Use of probiotics in metabolic syndrome and cardiovascular diseases. (Stavropoulou, 2020)

Applications of Probiotics in The Treatment and Control of Different Diseases

Gastrointestinal-Related Disease Control

Probiotics ingested into the body can directly or indirectly influence gut physiology by modulating the endogenous ecosystem or immune system, thus providing therapeutic potential. Probiotics have shown effectiveness in the prevention and treatment of many gastrointestinal disorders. Examples include antibiotic-associated diarrhea, H. pylori gastroenteritis, inflammatory bowel disease, irritable bowel syndrome, small intestine bacterial overgrowth, and lactose intolerance.

Metabolism-Related Disease Control

Metabolic syndromes such as hyperlipidemia, hypertension, diabetes and obesity are considered to be closely related to cardiovascular disease and seriously affect human health. Safe probiotics isolated from nature are considered as a new complementary strategy to prevent and improve lipid metabolism disorders and related chronic diseases. Probiotics influence the body's metabolism through metabolites that interact with the host or themselves.

Autoimmune Diseases Control

Evidence from animal models and humans suggests that dysregulation of gut microbes is associated with the development of certain autoimmune diseases. Probiotics and their related products can be used as effective treatments for autoimmune diseases, including type I diabetes, multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus, by modulating the intestinal microbiota and influencing the systemic immune response.

Cancer Prevention and Therapy

Probiotics have been shown to have a protective effect against cancer development in animal models. Some probiotic strains can reduce the incidence of postoperative inflammation in cancer patients. For example, diarrhea associated with chemotherapy or radiation therapy was relieved in patients given oral probiotics. Thus, some probiotic strains can be used as adjuvants for cancer prevention and treatment.

Neurological-Related Diseases Management

The bidirectional communication between the central nervous system and gut microbes is called the "microbiota-gut-brain axis". Dysfunction or altered microbiota composition and metabolic disorders between gut microbes and brain function can lead to the development of neurological related disorders, including brain diseases such as depression, Alzheimer's, schizophrenia, Parkinson's, autism, and multiple sclerosis. Therefore, the use of prebiotics or probiotics for the regulation of intestinal microorganisms brings the possibility of new and inexpensive therapeutic approaches.

Oral Health Management

Probiotics play a role in maintaining oral health by interacting with the oral microbiome. The most common applications are Lactobacillus rhamnosus GG and Bifidobacterium. They can control periodontal disease, dental caries and bad breath to affect the oral health of adults and children. Exploring the use of probiotics in the prevention, treatment and management of a number of oral diseases could open up the possibility of designing probiotics for the next generation of oral and throat supplemental healthcare development.

Creative Enzymes is a professional and experienced probiotic supplier and service provider. We provide high quality probiotic strains for disease treatment and management and related probiotic mechanism of action research services to provide scientific insights for our clients' related research and development projects. To get more information, please contact us and we will be happy to serve your research demands.

Reference

1. Stavropoulou, E.; et al. Probiotics in medicine: a long debate. Frontiers in immunology. 2020, 11: 2192.