Research on The Mechanism of Action of Probiotics

The health benefits that probiotics bring to the host have shown great potential. A clear understanding of the mechanism of action of probiotics can allow the selection of appropriate probiotic strains for specific applications and the possible discovery of new probiotic functions. As a leading service provider in the probiotic industry, Creative Enzymes is committed to using our experience and technology to provide probiotic mechanism of action research services to help our clients better apply and develop probiotics.

Overview

The mechanisms of action of probiotics are diverse. Understanding the mechanisms of action of probiotics can enable manipulation of probiotics to influence the host. Although some mechanisms by which probiotics exert their beneficial effects have been identified, there are significant differences between different probiotic bacterial species and strains. The main mechanisms of action of probiotics include colonization and normalization of the intestinal microbial community, competitive elimination of pathogens and production of bacteriocins, regulation of fecal enzyme activity associated with bile salt metabolism and inactivation of carcinogens and other xenobiotics, production of short-chain and branched-chain fatty acids. Therefore, research to elucidate the exact molecular mechanism of action of probiotics is necessary to help clients to select probiotics in a more rational way for development and application.

Fig. 1 Schematic representation of the crosstalk between probiotic bacteria and the intestinal mucosa. (Ng, 2009)

Research on The Immunomodulatory Mechanism of Probiotics

Mechanisms leading to probiotic-induced changes in immune function in vivo may include modulation of the microbiota itself, improvement of barrier function and thus reduction of immune exposure to the microbiota, and direct effects of bacteria on different epithelial and immune cell types. The impact of probiotics on the developing immune system is an area in which we are actively conducting research services. Creative Enzymes uses our advanced science combined with molecular biology approaches to help our clients understand how probiotics regulate host immune responses.

Research on Probiotic-Host Interactions and Potential Mechanisms

The interaction between probiotics and the intestinal host is complex and multifactorial. These receptors recognize multiple effector molecules in bacteria, most of which are found to be cell wall or cell surface-associated compounds and proteins. Creative enzymes assess the complex interactions of probiotics with their hosts through molecular biology approaches, including macrogenomic as well as bioinformatics tools. We are committed to applying our science to help our clients uncover the mechanisms by which probiotics regulate cellular signaling networks and their associated effects on downstream regulatory pathways.

Creative Enzymes is a professional and experienced probiotic supplier and service provider. We leverage a variety of advanced technologies and tests to help our clients study the mechanism of action of probiotics. To get more information, please contact us and we will be happy to serve your research demands.

Reference

1. Ng, S. C.; et al. Mechanisms of action of probiotics: recent advances. Inflammatory bowel diseases. 2009, 15(2): 300-310.