Selection of Superior Strains
The mechanism of action of probiotics is directly related to the characteristics of the selected probiotic strain. Selection and breeding of probiotic bacteria is an important challenge and requires a platform that provides basic information on candidate strains. As a professional probiotic development service provider, Creative Enzymes can provide cost-effective solutions for any of our clients' high-end, high-quality products.
Our Strain Selection Criteria
When helping our clients develop probiotic products, the first step is to select an excellent strain of bacteria. In this process, we have developed a set of scientific selection criteria. We perform detailed researches on the origin, genomic composition and growth characteristics of the selected strains, which are necessary to consider the origin, in vitro and in vivo genetics and growth characteristics of the strains.
Our detailed selection criteria include the following.
- Capable of producing beneficial effects on the host.
- Withstand into food stuff at a high cell count.
- Maintains vitality throughout the product's shelf life.
- Capable of withstanding transport through the gastrointestinal tract.
- Adheres to the lining of intestinal epithelial cells and colonizes the lumen of the intestine.
- Produces antibacterial substances against pathogens.
- Technologically suitable for industrial processes.
Strain Selection Services at Creative Enzymes
Creative Enzymes screens strains on a large scale through a high-throughput, automated screening platform. Our advanced screening technology can be applied to the screening of different species and strains of probiotics due to the diversity of our screening samples.
Creative Enzymes always adheres to the customer-centric principle. Under the premise of fully understanding clients' demands, we design suitable screens based on the growth characteristics of strains, physiological and biochemical properties, genetic and metabolic information, and analysis of the impact on nutrition and clinical pathology of different populations. The analytical tests during high-throughput screening mainly include the growth of the bacteria and their metabolic properties, such as nutrient-deficient type, tolerance, hydrolysis circle, chromogenic circle, inhibition circle, and fluorescence or chromogenicity of the target object. Our experienced scientific team will design and optimize the screening method by combining the characteristics of the strains with various methodological principles. In addition, the selected strains are followed up with validation, evaluation and safety analysis to ensure the effectiveness and safety of the strains.
Fig. 1 Functional strain screening process at Creative Enzymes.
Our Methods
Creative Enzymes provides our clients with multiple advanced screening methods, mainly including:
- MS-based high-throughput mass spectrometry screening.
- Droplet microfluidic screening.
- Micro-titration plate-based screening.
- Fluorescence imaging-based screening.
Why Choose Us
- High-throughput screening technology makes complex screening processes simple and efficient.
- Customized screening process ensures the selection of superior strains.
- A complete screening, validation and safety analysis process ensures high quality results delivery from the source.
Creative Enzymes is a professional and experienced probiotic supplier and service provider. We adopt advanced screening strategies and scientific evaluation processes to ensure that our probiotic products development solutions are manufactured to specification. To get more information, please contact us and we will be happy to serve your research demands.
