Evolutionary Engineering Enhanced Strategies to Improve Probiotics
Engineering modifications of probiotics are widely used for the selection of probiotic bioactives and further enhancement of their activity. Creative Enzymes provides clients with engineered evolutionary strategies for probiotics, including mutagenesis, adaptive domestication techniques, genetic modification services, and combination strategies of different approaches.
Introduction to The Engineering Evolutionary Strategy of Probiotics
Evolutionary engineering strategies are more commonly used in biological research to improve biological properties, mainly including mutagenesis, adaptive evolution and genome modification. With the rapid development of whole genome sequencing, the combination of adaptive evolutionary strategies with gene expression and metabolic flux analysis has enabled genetically based identification of improved phenotypes and the transmission of such phenotypes between strains. Creative Enzymes develops and improves strains through our advanced technologies to obtain production strains with higher yields, better stability, lower toxicity, shorter fermentation times, and lower substrate costs.
Our Methods
Mutagenesis as an effective way to improve strain characteristics can accelerate the conversion of the original strain to an industrial strain. Creative Enzymes offers a variety of mutagenesis methods to improve strain performance, including chemical mutagenesis, physical mutagenesis, and site-directed mutagenesis. In practical applications, we will combine different mutagenic methods to further improve the mutation efficiency and obtain ideal strains.
Adaptive evolution has a strong evolutionary purpose and is a circular process alternative between genetic diversification and genetic screening for the selection of desired genetic variants. Creative Enzymes use environmental pressure to progressively domesticate and screen strains to eventually obtain high performance and stable strains to meet the demands of commercial development of probiotics.
Genetic recombination is a newly developed technique of directed evolution following adaptive evolution. By combining traditional mutagenesis with protoplast fusion techniques, Creative Enzymes' scientists have dramatically increased the frequency of positive mutations in strains, thereby improving their traits and enabling them to be inherited stably.
Advantages of Creative Enzymes
- Extensive experience in probiotic strain optimization.
- Provide personalized service according to the characteristics of probiotic strains.
- Provides various mutation methods for gene variant library construction.
- Provide an efficient and professional portfolio of services and delivery of results.
Workflow of Creative Enzymes
Fig. 1 Project workflow of Creative Enzymes.
Creative Enzymes is a professional and experienced probiotic supplier and service provider. We are proud to have successfully applied our science to develop and improve various strains for our clients, helping them to obtain the ideal strain for industrial production. To get more information, please contact us and we will be happy to serve your research demands.
