Oral Toxicity Tests of Probiotics
Oral toxicity is the most basic and essential toxicity test, which can predict the basic toxicity information and adverse reaction level of probiotic products in advance. Creative Enzymes provides more information on the potential toxicological risks of probiotics through our animal tests.
Overview
Oral toxicity is a test performed on probiotic products and is an important component of the in vivo safety evaluation of probiotics. Before probiotic products are registered to enter the market, detailed toxicity test data is required to support their safety. Oral toxicity tests are usually performed in rodents and can take many forms, but the main purpose is the same. Toxicity is usually assessed in acute, subacute, subchronic and chronic duration studies based on the expected exposure time of the products. Creative Enzymes' scientific team uses our expertise and experience to design a test procedure to identify the potential risks posed by the product.
Oral Toxicity Tests Provided by Creative Enzymes
Creative Enzymes offers a wide range of oral toxicity tests. In order for our test results to better predict possible harmful effects in humans, we have developed a standardized testing process. Our standardized tests are divided into single (acute) dose toxicity test and repeated dose (subacute, subchronic and chronic) toxicity tests, depending on the duration of administration. The following toxicity tests are what we do.
| Testing Methods | Description | Dosage | Observation Time |
|---|---|---|---|
| Acute oral toxicity | The first tests were conducted, providing data on relative toxicity from single or brief exposures. | Three dose levels recommended; exposures are single doses or fractionated doses up to 24 hours for oral or dermal studies and 4-hour exposure for inhalation studies. | 14 days |
| Subacute oral toxicity | Carried out after initial information on toxicity has been obtained by acute toxicity test. | Based on daily oral administration in graduated doses of the test substance/probiotics to several groups of experimental animals, one dose level per group for a period of 28 days. | 28 days |
| Subchronic oral toxicity | Test for possible toxicity from repeated exposures of several weeks to several months. | Three dose levels plus a control group; include a toxic dose level plus NOAEL; exposures are 90 days. | 90 days |
| Chronic oral toxicity | Commonly used to test the toxicity of animals exposed to longer periods of time and involving larger animal populations. | Three dose levels recommended; includes a toxic dose level and NOAEL; exposures generally 12 months or longer. | 12-14 months |
Services of Creative Enzymes
- Preliminary testing of acute toxicity in mice.
- Select the appropriate route of administration according to the characteristics of the product to be tested.
- Histopathological examination of some suspect animals.
Testing Process of Creative Enzymes
Creative Enzymes provides our clients with a one-stop standardized testing process to help them test their products for possible toxicity or risk to consumers. What you need to do is provide us with the samples to be tested and we will provide you with reliable test results in a timely manner.
Creative Enzymes is a professional and experienced probiotic supplier and service provider. We combine leading industry knowledge with standardized testing, so we can meet any of our clients' oral toxicity testing demands and provide detailed toxicological assay data. To get more information, please contact us and we will be happy to serve your research demands.
