Probiotics Dosage Form Development Service
Probiotics need stable probiotic dosage forms to overcome various physicochemical, biopharmaceutical and biological barriers and maximize their therapeutic efficacy and clinical applicability in the course of their action. Creative Enzymes provides a variety of probiotic dosage form development technologies to help our clients develop probiotic products, so as to better obtain stable and effective products.
Obstacles in The Application Process of Probiotic Products
- Biological Factors
Probiotics are exposed to the harsh environment of the gastrointestinal tract after oral administration. Highly acidic gastric juice (pH 1-3) and a gastric emptying time of approximately 2 hours significantly reduce the viability of probiotics in the stomach. Thus, acid resistance is a key factor and a desirable property of oral probiotic delivery systems.
- Pharmaceutical Factors
During manufacturing and storage, probiotics are exposed to a variety of stressful conditions that affect their stability, including heat, oxygen levels, mechanical forces, osmotic shock, and pH changes. Therefore, the development process of probiotics is very important.
Protecting probiotics from these stresses is one of the main goals of Creative Enzymes dosage form development, and we are committed to using our expertise and technology to provide scientifically reliable dosage form development services.
Our Services
- Dosage Form Development
Creative Enzymes has tried various methods of dosage form development through different routes of administration to maximize the therapeutic benefits of probiotics. Our experienced scientists are well aware of the advantages and limitations of each route of administration. Therefore, our dosage form development strategy may vary depending on the route of administration, probiotic strain and therapeutic area. We are committed to providing customized dosage form development solutions based on the characteristics of the strains themselves and the development needs of our clients.
- Dosage Form Characterization
We use advanced technology to evaluate the various properties of the developed dosage forms. For example, for the developed granules products, we focus on further testing and characterization of properties such as shape, size, porosity, surface properties, density, water activity, glass transition temperature, and cohesiveness. Our attention to detail ensures that we provide our clients with probiotic products that meet quality standards and specifications.
Customizable Dosage Forms
| Dosage Form | Description | Advantages |
|---|---|---|
| Oral Films | Typically consisting of active ingredient products, film-forming polymers and plasticizers, and used in combination with functional excipients (including sweeteners, flavors and colors) according to specific demands. | Easy to administer without water, no risk of choking, easy to transport and fast acting. |
| Power | Powder preparation is developed by combining spray drying and freeze-drying processes, etc. | Fast dissolution, low cost and flexibility in mixing solids. |
| Granules | The process involves wet or dry granulation to yield free-flowing agglomerated particles with desired physical properties. | Suitable for dispensing large doses of probiotics, easy to consume, with better flowability and compressibility. |
| Capsules/ Tablets | Provides a convenient solid dosage form of probiotics. | Allows the application of various functional excipients to improve shelf life, GI stability, cell viability, and control the release rate and target sites of probiotics. |
| Orodispersible Tablet | ODT is manufactured by direct compression or granulation with probiotics and then blended into tablets. | Convenient, fast-acting and can improve its effectiveness in the treatment of oral diseases such as dental caries, gingivitis or periodontitis. |
| Hydrogel | Hydrogels are three-dimensional cross-linked networks of water-soluble polymers. A hydrogel can be formulated as micro-/nano-particles or as films using biopolymers and/or polyelectrolytes. | Features adjustable physical properties, biocompatibility, ability to protect against drug degradation and controlled drug release. |
| Others | Vaginal suppositories, chewing gums and lozenges, eye drops. | |
Creative Enzymes is a professional and experienced probiotic supplier and service provider. We are committed to providing a full range of probiotic dosage form development services from initial sample to final dosage form characterization. To get more information, please contact us and we will be happy to serve your research demands.
