Application of Probiotics in Metabolism-Related Diseases
The prevalence of metabolic syndromes such as hyperlipidemia, hypertension, diabetes and obesity are increasing due to global changes in lifestyle, diet structure and aging. Probiotics can regulate metabolic syndrome by modulating the gut microbiota and are expected to be a new agent for the treatment of metabolic syndrome. With researches on the mechanism of action of probiotics and their effects on human health, Creative Enzymes provides our clients with the ideal strain and manufacturing services for the treatment of metabolism-related diseases and offers probiotic products in any form.
Mechanisms of Probiotics Regulation of Metabolism-Related Diseases
Metabolic disorders are a serious health problem that leads to a variety of health damages. Probiotics have potential roles in the intestinal flora to modulate lipid metabolism, obesity and insulin resistance in the body to varying degrees, mainly including the following.
- Promoting fatty acid oxidation and reducing fatty acid synthesis in the liver.
- Promoting intestinal development and digestion, balances the small intestinal gut microbiota, and reduces fat accumulation to lower cholesterol.
- Lowering of serum TC and TG.
- Some probiotics can lower LDL and increase HDL.
- Changing the structure of the intestinal microbiota to increase the proportion of beneficial bacteria, such as Lactobacillus and Bifidobacterium.
Fig. 1 An overview of the microbiome's role in development of obesity and metabolic syndrome. (Green, 2020)
Probiotics for Metabolism-Related Diseases
Different probiotics have different effects on metabolism and this result may depend on the strain, dosage and composition used to produce a particular probiotic product. Creative Enzymes can provide probiotic strains for metabolism-related diseases and can provide customized probiotic formulations for specific therapeutic demands. The following describes the probiotics we offer that can be used in metabolism-related diseases and their effects, mainly Lactobacillus.
| Probiotics | Role in The Treatment of Metabolism-Related Diseases |
|---|---|
| Lactobacillus plantarum | Preventive and therapeutic effects on diabetes, obesity, non-alcoholic fatty liver disease, kidney stone disease and cardiovascular disease. The ability to reduce levels of inflammation and oxidative stress by modulating the production of cytokines and short-chain fatty acids (SCFAs), the activity of antioxidant enzymes, and the balance of the gut microbial community to reduce the symptoms of chronic metabolic diseases. |
| Lactobacillus rhamnosus | It is a potential probiotic strain for obesity prevention, showing strain-specific effects in improving pro-inflammatory processes by reducing inflammatory macrophage infiltration and expression of inflammation-associated genes. |
| Lactobacillus bulgaricus | Significantly reduces lipid accumulation and inhibits adipocyte differentiation by downregulating adipose transcription factors in adipocytes, lowering cholesterol levels. |
| Bifidobacterium bifidum | Reducing the risk of obesity and improves serum total cholesterol, fasting glucose and insulin levels. Acts by regulating the expression of genes related to fat metabolism and insulin sensitivity. |
Our Capabilities
- Screening and validation of personalized probiotics for various metabolic syndromes.
- Providing customized probiotic formulations for different metabolism-related diseases.
- Development and manufacture of probiotic products for metabolism-related diseases.
- Efficacy and safety assessment of probiotic products.
- In-depth investigation into the pathways of action of probiotics in regulating metabolic syndrome and their mechanisms.
Creative Enzymes is a professional and experienced probiotic supplier and service provider. Our years of experience in probiotics means we can provide stable and safe strains as well as production development services to create effective probiotic solutions for metabolism-related diseases. To get more information, please contact us and we will be happy to serve your research demands.
Reference
- Green, M.; et al. Microbial medicine: prebiotic and probiotic functional foods to target obesity and metabolic syndrome. International journal of molecular sciences. 2020, 21(8): 2890.
